Chapter 12

12From Sequence to Regulatory Function

Draft pending — this page is an outline of planned content. Write it by creating content/sequence-to-function.md.

12.1The problem: predicting function from DNA

Planned: What regulatory activity a stretch of genome will have.

12.2Models that attempt it

Planned: The Enformer and Borzoi line predicting expression, accessibility, and 3D contacts; DNA language models.

12.3What they do well and what is still hard

Planned: Cross-gene accuracy vs poor personal, inter-individual variation; long-range regulation.